Matthew J. DeOrio, MD


Dr. DeOrio specializes in the medical and surgical treatment of acute and chronic conditions of the foot and ankle. He evaluates patients of all ages and treats sprains and fractures, as well as chronic deformity and arthritis that contributes to pain in the foot and ankle. His practice is 50% clinical and 50% surgical. He can make recommendations on shoe wear and help determine when it is appropriate to use over-the-counter shoe inserts and bracing versus custom orthotic and bracing.

During his undergraduate education, Dr. DeOrio was a four-year letterman at Duke University in football. After earning his medical degree from the University of South Florida, Dr. DeOrio completed his orthopaedic surgery residency at Mayo Clinic and his Foot & Ankle fellowship at Duke University Medical Center.

Dr. DeOrio is board-certified in orthopaedic surgery and is a fellow of both the the American Orthopaedic Foot and Ankle Society (AOFAS) and American Academy of Orthopaedic Surgeons (AAOS).

Dr. DeOrio has performed more ankle replacements than any other surgeon in the area. He has extensive experience with many prostheses including the Agility, Salto Talaris, STAR, and Infinity implants. He currently uses the Vantage, INBONE, and INVISION prostheses for primary and revision ankle replacement surgery.

Dr. DeOrio often makes both surgical and nonsurgical treatment plans for patients who suffer from Charcot arthropathy, a diabetic condition of the foot and ankle that can cause significant deformity.

Dr. DeOrio enjoys distance running and to date has completed over 12 marathons and ultramarathons. His next goal is to complete an Ironman. His experience in distance running has given him added insight into both common and unique injuries experienced by runners. When not running, you may find him surfing or scuba diving. He is also an avid gardener and has an extensive garden grown from seed, large succulent and citrus collection, and grafts Japanese Maples.

He is a proud father of Madison and Tyler.

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Areas of Expertise


  • American Orthopaedic Foot and Ankle Society
  • American Academy of Orthopaedic Surgeons
  • Alabama Orthopaedic Society

Patient Resources

Achilles Tendinopathy – Noninsertional
Achilles Tendinopathy – Insertional (GRAPHIC)
Chronic Achilles Tendinopathy Treated with Eccentric Stretching Program
Musculoskeletal Effects of Cigarette Smoking
Plantar Fasciitis


Bunionette Deformity Correction

TOC Talks

Ankle Replacement


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